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Nucleic Acids Research, 1984, Vol. 12, No. 21 8219-8233
© 1984

CHEMISTRY

Studies on the conformation and dynamics of the C8-substituted guanlne adduct of the carcinogen acetytaminofluorene; model for a possible Z-DNA modified structure

Stephen Neidle1, Reiko Kuroda2, Suse Broyde4, Brian E. Hingerty3, Robert A. Levine4, Dwight W. Miller4 and Frederick E. Evans4

1Cancer Research Campaign Biomolecular Structure Research Group, Department of Biophysics, King's College University of London London WC2B 5RL, UK 2Biology Department, New York University NY 10003, USA 3Health and Safety Research Division, Oak Ridge National Laboratory Oak Ridge, TN 37830, USA 4Division of Chemistry, National Center for Toxicological Research Jefferson, AK 72079, USA

Received September 11, 1984. Revised October 11, 1984. Accepted October 11, 1984.

The structure of an adduct between guanine and the carcinogen acetylaminofluorene has been examined in the solid state by X-ray crystallography, and in solution by NMR techniques. The observed conformations have been compared with predictions from energy calculations and their relevance to models of adducts with DNA has been examined.


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