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Nucleic Acids Research, 1984, Vol. 12, No. 22 8313-8318
© 1984

MOLECULAR BIOLOGY

Erythromycin and spiramycin resistance mutations of yeast mitochondria: nature of the rib2 locus in the large ribosomal RNA gene

Frédéric Sor and Hiroshi Fukuhara

Institut Curie, Section de Biologie, Båtiment 110, Centre Universitaire 91405 Orsay, France

Received October 9, 1984. Accepted October 25, 1984.

Two linked genetic loci, rib 2 and rib 3, of yeast mitochondrial genome are the sites of mutations that confer resistance to erythromycin and/or spiramycin. We have examined two mutations at the rib 2 locus. Mutation ER354 was found at the nucleotide position 3993 of the large ribosomal RNA gene ; it corresponded to a C to G transversion leading to a double resistance to erythromycin and spiramycin. Mutation SR551 was found also at the same position, but the C was replaced by a T, conferring resistance to spiramycin only.Rib 2 and rib 3 are 836 base pairs apart on the gene sequence, but are very close to each other in the secondary structure of ribosomal RNA.


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