Skip Navigation

This Article
Right arrow Print PDF (934K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (80)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Citron, B.
Right arrow Articles by Darnell, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Citron, B.
Right arrow Articles by Darnell, J. E., Jr.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1984, Vol. 12, No. 22 8723-8731
© 1984

MOLECULAR BIOLOGY

Transcription termination occurs within a 1000 base pair region downstream from the poly(A) site of the mouse ß-globin (major) gene

Bruce Citron, Erik Falck-Pedersen, Marianne Salditt-Georgieff and James E. Darnell, Jr.

The Rockefeller University New York, NY 10021, USA

Received July 16, 1984. Revised October 24, 1984. Accepted October 24, 1984.

Transcription of RNA from the ß-globin (major) gene in nuclei from induced mouse erythroleukemia cells terminates within the region between 700 to 2000 bases downstream from the poly (A) addition site, but not at particularly favored sites. In addition we present the first analysis of in vivo labeled RNA from a cell transcription unit that shows RNA termination in the same region as diagnosed by analysis of in vitro labeled RNA. The region in which termination occurs is contained in 1414 bp that were sequenced beginning 600 bases downstream from the poly(A) site. There is an increased frequency of the sequence AATAAA at the beginning and a stem and loop structure followed by a string of Ts near the end of this region.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 RNAHome page
S. WEST, K. ZARET, and N. J. PROUDFOOT
Transcriptional termination sequences in the mouse serum albumin gene.
RNA, April 1, 2006; 12(4): 655 - 665.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
E. Fuhrmann-Benzakein, I. Garcia-Gabay, M. S. Pepper, J.-D. Vassalli, and P. L. Herrera
Inducible and irreversible control of gene expression using a single transgene
Nucleic Acids Res., December 1, 2000; 28(23): e99 - e99.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. A. Flaspohler, D. Boczkowski, B. L. Hall, and C. Milcarek
The 3`-Untranslated Region of Membrane Exon 2 from the [IMAGE]2a Immunoglobulin Gene Contributes to Efficient Transcription Termination
J. Biol. Chem., May 19, 1995; 270(20): 11903 - 11911.
[Abstract] [Full Text] [PDF]

Home page
 Genes Dev.Home page
S Roberts, T Purton, and D L Bentley
A protein-binding site in the c-myc promoter functions as a terminator of RNA polymerase II transcription.
Genes & Dev., August 1, 1992; 6(8): 1562 - 1574.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
P Labhart and R H Reeder
A point mutation uncouples RNA 3'-end formation and termination during ribosomal gene transcription in Xenopus laevis.
Genes & Dev., February 1, 1990; 4(2): 269 - 276.
[Abstract] [PDF]

Home page
 Genes Dev.Home page
S Connelly and J L Manley
A functional mRNA polyadenylation signal is required for transcription termination by RNA polymerase II.
Genes & Dev., April 1, 1988; 2(4): 440 - 452.
[Abstract] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.