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Nucleic Acids Research, 1984, Vol. 12, No. 23 8939-8949
© 1984

CHEMISTRY

Synthesis of deoxyoligonucteotides containing 7-deazaadenine: recognition and cleavage by restriction endonuclease Bgl II and Sau 3AI (Nucleosides and Nucleotides Part 551)

Akira Ono, Masayuki Sato, Yutaka Ohtani and Tohru Ueda*

Faculty of Pharmaceutical Sciences, Hokkaido University Sapporo 060, Japan

*To whom correspondence should be addressed

Received August 29, 1984. Revised November 14, 1984. Accepted November 14, 1984.

Deoxydecanucleotides having a recognition sequence of Bgl II and Sau 3AI, and their 7-deazaadenine analogs were synthesized. The decanucleotides containing 7-deazaadenine in place of adenine were partially resistant to the hydrolysis by Sau 3AI and strongly resistant to that by Bgl II. A new hypothesis on the mode of recognition and cleavage of specific nucleotide sequences by Bgl II, recognizing one strand and cleaving the other strand, is presented.


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