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Nucleic Acids Research, 1984, Vol. 12, No. 3 1427-1446
© 1984

MOLECULAR BIOLOGY

Post-transcriptional regulation of the chicken thymidine kinase gene

Mark Groudine* and Colin Casimir

Fred Hutchinson Cancer Research Center 1124 Columbia Street, Seattle, WA 98104 *Department of Radiation Oncology, University of Washington Hospital Seattle, WA 98195, USA

Received November 14, 1983. Accepted December 14, 1983.

In attempting to understand the molecular basis of the control of chicken thymidine kinase (cTK) gene expression, we have examined the steady state cTK RNA content, and the patterns of DNA methylation, chromatin structure and endogenous nuclear runoff transcription of this gene in dividing and non-dividing cells. Our results reveal that the steady state level of cTK poly A+ RNA is correlated with the divisional activity of normal avian cells and tissues. However, no differences in the pattern of Hpa II site methylation or chromatin structure are found among cells containing high or undetectable levels of steady state cTK RNA. In addition, no differences in cTK transcription aa assayed by nuclear runoff experiments are detectable in isolated nuclei derived from dividing or non-dividing cells containing high or low levels of steady state cTK RNA. These results suggest that the principal control of chicken thymidine kinase gene expression is post-transcriptional in nature.


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