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Nucleic Acids Research, 1984, Vol. 12, No. 3 1641-1655
© 1984

MOLECULAR BIOLOGY

Ruminant globin gene structures suggest an evolutionary role for Alu-type repeats

John C. Schimenti and Craig H. Duncan*

Room IDR 704, Children's Hospital Research Foundation, Elland and Bethesda Avenues, and University of Cincinnati Medical School Graduate Program in Developmental Biology, Cincinnati, OH 45229, USA

*To whom reprint requests should be sent

Received October 24, 1983. Accepted December 12, 1983.

Bovine fetal and adult globin genes were cloned and subjected to DNA sequence analysis. Both of these genes contained insertions of Alu-type repetitive DNA within their introns. Comparison of cow and goat ß-type globin genes indicates that intragenic DNA insertions played a role in their evolution. These data support the theory that Alu-type repeats maintain genetic diversity by inhibiting gene conversion.


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