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Nucleic Acids Research, 1984, Vol. 12, No. 4 1889-1900
© 1984

MOLECULAR BIOLOGY

Initiation of transcription in yeast mitochondria: analysis of origins of replication and of genes coding for a messenger RNA and a transfer RNA

K. A. Osinga, G.T.J. Van der Horst and H.F. Tabak

Section for Molecular Biology, Laboratory of Biochemistry, University of Amsterdam Kruislaan 318, 1098 SM Amsterdam, The Netherlands

Received December 1, 1983. Revised January 27, 1984. Accepted January 27, 1984.

The initiation of transcription of the yeast mitochondrial genes coding for subunit I of cytochrome c oxidase (COX1) and for Formula has been examined. COX1 messenger RNA synthesis is initiated in a conserved nonanucleotide sequenne (ATATAAGTA) which we have previously found immediately upstream of riboaomal RNA genes at positions at which RNA synthesis starts. The 5'-end of the precursor of Formula is located in a variant nonanucleotide motif (TTATAAGTA), which may be characteristic for tRNA genes. Using a partially purified fraction of mtRNA polymerase, we demonstrate that RNA synthesis is precisely initiated in vitro in nonanucleotide sequences preceding both ribosomol RNA-, tRNA- and messenger RNA-encoding genes and origins of replication.


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