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Nucleic Acids Research, 1984, Vol. 12, No. 4 1961-1975
© 1984

MOLECULAR BIOLOGY

Tetrahymena H4 genes: structure, evolution and organization in macro- and micronuclei

Gary A. Bannon, Josephine K. Bowen, Meng-Chao Yao, Meng-Chao Yao* and Martin A. Gorovsky

Department of Biology, University of Rochester Rochester, NY 14627 *Department of Biology, Washington University St. Louis, MO 63130, USA

Received October 19, 1983. Accepted January 20, 1984.

The ciliated protozoan Tetrahymena thermophila contains two types of H4 histone genes (H4-I and H4-II). Southern blotting and analysis of DNA from nullisomic strains indicate that H4-I and H4-II are on different chromosomes and that only 114-II is closely linked to an H3 gene. No DNA sequence rearrangeoments are observed for either of the H4 genes when the transcriptionally inert, germ line, micronucleus is compared to the transcriptionally active, somatic inacronucleus. Comparison of the H4-I gene and its flanking sequences to H4 gene sequences of other organisms indicates that there are evolutionary constraints on coding nucleotides that are unrelated to their protein coding function and that these evolutionary pressures operate at the level of translation.


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