Skip Navigation

This Article
Right arrow Print PDF (855K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (78)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Whitton, J. L.
Right arrow Articles by Clements, J. B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Whitton, J. L.
Right arrow Articles by Clements, J. B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1984, Vol. 12, No. 4 2061-2079
© 1984

MOLECULAR BIOLOGY

Replication origins and a sequence involved in coordinate induction of the immedlate-early gene family are conserved in an intergenic region of herpes simplex virus

J. Lindsay Whitton+ and J. Barklie Clements*

Institute of Virology, University of Glasgow Church Street, Glasgow G11 5JR, UK

*To whom correspondence should be addressed

Received January 5, 1984. Accepted January 31, 1984.

We have determined the structure of the 5' portion of herpes simplex virus type 2 (HSV-2) immediate-early (IE) mRNA-3 and have obtained the DNA sequence specifying the N terminus of its encoded polypeptide, Vmw182, its untranslated leader and the intergenic region between IEmRNAs-3 & -4/5. Comparison of the HSV-2 intergenic sequences with the HSV-1 equivalent region identifies several conserved regions: (1) an AT-rich element with core consensus TAATGARAT which is likely to be the ‘activator’ sequence through which coordinate induction of the IE gene family is mediated. (2) GC-rich and GA-rich tracts, found in a wide variety of eukaryotic promoters, which vary in position and orientation between HSV-2 and HSV-l and which represent modulators of transcription. (3) TATA homologies present 15–25 base pairs (bp) upstream of mRNA 5' termini. (4) a l37bp direct repeat in HSV-2 which contains sequence almost identical to the HSV-l replication origin.

+ Present address: Scripps Clinic and Research Foundation, 10666 North Torrey Pines Road, La Jolla, CA 92037, USA


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Virol.Home page
B. C. Summers and D. A. Leib
Herpes Simplex Virus Type 1 Origins of DNA Replication Play No Role in the Regulation of Flanking Promoters
J. Virol., June 14, 2002; 76(14): 7020 - 7029.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. T. Nguyen-Huynh and P. A. Schaffer
Cellular Transcription Factors Enhance Herpes Simplex Virus Type 1 oriS-Dependent DNA Replication
J. Virol., May 1, 1998; 72(5): 3635 - 3645.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
A. Dolan, F. E. Jamieson, C. Cunningham, B. C. Barnett, and D. J. McGeoch
The Genome Sequence of Herpes Simplex Virus Type 2
J. Virol., March 1, 1998; 72(3): 2010 - 2021.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.