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Nucleic Acids Research, 1984, Vol. 12, No. 4 2147-2156
© 1984

MOLECULAR BIOLOGY

Complete c-mos (rat) nucleotide sequence: presence of conserved domains In c-mos proteins

F.A. Van der Hoorn and J. Firzlaff

Swiss Institute for Experimental Cancer Research 1066 Epalinges, Switzerland

Received December 1, 1983. Revised February 1, 1984. Accepted February 1, 1984.

Recently we described the isolation of c-mos (rat). The gene belongs to the family of oncogenes. Some facts render c-mos unique among the onco-genes : a) it does not contain intervening sequences and b) its expression was never detected in a large number of normal mouse tissues examined. We undertook the sequence analysis of c-mos (rat) in order to compare it to the nucleotide sequences published for c-mos (mouse), c-mos (human), c-src and bovine protein kinase. c-mos (rat) contains an open reading frame of 1017 nucleotides, coding for a polypeptide of 339 amino acids. c-mos (rat)-makes use of the same ATG that defines the N-terminus of the c-mos (human) protein. By comparing all c-mos sequences available we found sequences with high mutational rates to be confined to certain domains. This comparison, together with data on the biological activities of the cloned DNA, allowed us to tentatively define regions involved in (a) function(s) of c-mos other than transformation.


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