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Nucleic Acids Research, 1984, Vol. 12, No. 5 2273-2282
© 1984

MOLECULAR BIOLOGY

‘Solo’ large terminal repeats (LTR) of an endogenous retrovirus-like gene family (VL30) in the mouse genome

Galit Rotman, Ahuva Itin and Eli Keshet

Department of Virology, Hebrew University, Hadassah Medical School Jerusalem 91010, Israel

Received January 12, 1984. Accepted February 6, 1984.

VL30 genetic elements constitute a murine multicopy gene family that is retrovirus-like, despite the lack of sequence homology with any known retrovirus. Over one hundred copies of VL30 units are dispersed throughout the mouse genome. We report here that the mouse genome also contains ‘solo’ VL30 long terminal repeats (LTRs). These are structures which contain the LTR detached from the rest of the VL30 sequences. The isolation of solo LTRs from a mouse embryonic gene library with the aid of sub-genomic VL30 probes is described. Direct DNA sequencing established that the solo LTR unit is grossly similar to a standard VL30 LTR and that the LTR is flanked by a 4-base pair duplication. The analogy to the occurance of solitary LTR units of transposable elements is discussed.


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