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Nucleic Acids Research, 1984, Vol. 12, No. 5 2439-2446
© 1984

MOLECULAR BIOLOGY

Sequence of human adenogine deaminase cDNA Including the coding region and a small Intron

Dan A. Wiginton, Gwendolyn S. Adrian and John J. Hutton*

Department of Medical University of Texas Health Science Center and Audie L.Murphy Memorial Venterans Hospital San Antonio, TX 78284, USA

*To whom correspondence should be addressed

Received January 27, 1984. Accepted February 6, 1984.

The nucleotide sequence for an unusual, cloned human adenosine deaminase cDNA has been determined. Contained within a sequence of 1535 nucleotides is a coding sequence of 1089 nucleotides that encodes a protein of 40,762 daltons. The coding sequence is interrupted by a non-coding region containing 76 nucleotides. Both the 3' and 5' ends of this region have consensus sequences generally associated with splice sites. The 3' untranslated sequence contained 308 nucleotides, including a polyadenylation signal sequence 20 nucleotides from the end. The cloned cDNA appears to correspond to a nuclear mRNA precursor which contains a small intron.


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