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Nucleic Acids Research, 1984, Vol. 12, No. 7 3057-3068
© 1984

MOLECULAR BIOLOGY

A DNA-recombinogenic activity in human cells

Kerstin Kenne1 and Siv Ljungquist2

1Department of Medical Cell Genetics, Medical Nobel Institute, Karolinska Institute Box 60400 S-104 01 Stockholm, Sweden 2National Institute of Environmental Medicine, Unit of Toxicology Box 60208, S-104 01 Stockholm, Sweden

Received January 23, 1984. Accepted March 13, 1984.

A DNA recombining protein has been partly purified from cell lines derived from patients suffering from the hereditary disease, Bloom's syndrome. The protein induces the formation of displacement loops in øX174 RFI DNA molecules after the addition of single–stranded DNA fragments. A filter binding method and electron microscopy were used to determine the reaction. The recombinogenic protein is dependent on divalent cations and ATP for activity.


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