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Nucleic Acids Research, 1984, Vol. 12, No. 8 3445-3460
© 1984

MOLECULAR BIOLOGY

Unusual long terminal repeat sequence of a retrovirus transmissible mouse (VL 30) genetic element: identification of functional domains

John D. Norton*, Jane Connor* and Roger J. Avery+

*Department of Biological Sciences, University of Warwick Coventry CV4 7AL, UK +Department of Veterinary Science, Veterinary Research Laboratory, Montana State University Bozerman, MT 59717, USA

Received February 24, 1984. Accepted April 5, 1984.

We have determined the nucleotide sequence and mapped the tranacriptional boundaries in the long terminal repeats (LTRs) and adjacent regions of a retrovirus transmisaible virus-like 30S (VL30) mouse genetic element. The 572 base pair LTRs contain transcriptional regulatory sequences and are bounded by short imperfect repeats, with a minus strand tRNAgIy primer binding site and a purine rich plus strand primer site flanking each of their inner boundaries. The 3' end of each LTR consists of an extensive 80 base pair redundancy of tRNA primer site and inverted repeat sequences while 41 and 47 base pair imperfect tandem repeats are present between the 5' capping site and the putative polyadenylation signal. Comparison with other retrovirus-like LTR sequences suggests possible modes of recmbination that could occur between VL30 and other genetic elements.


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Sequence Analysis of Mus dunni Endogenous Virus Reveals a Hybrid VL30/Gibbon Ape Leukemia Virus-Like Structure and a Distinct Envelope
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