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Nucleic Acids Research, 1984, Vol. 12, No. 8 3707-3723
© 1984

MOLECULAR BIOLOGY

Structural organization of transposable element mdg4 from Drosophila melanogasler and a nucleotide sequence of its long terminal repeats

A.A. Bayev, Jr.2, N.V. Lyubomirskaya1, E. B. Dzhumagaliev1, E.V. Ananiev2, I. G. Amiantova3 and Y.V. Ilyin1,+

2N.I.Vavilov Institute of General Genetics, USSR Academy of Sciences Gubkin str., Moscow, USSR 1Institute of Molecular Biology, USSR Academy of Sciences Vavilov str., 32, Moscow 117984, USSR 3Institute of Molecular Genetics, USSR Academy of Sciences Kurchatov sq. 46, Moscow, USSR

+To whom reprint requests should be addressed

Received December 15, 1983. Revised March 20, 1984. Accepted March 20, 1984.

A mobile dispersed genetic element, mdg4,{small tilde} 7.5 kilobases (kb) long has been cloned from D. melanogaster genoine. Chromosomal bands have only few sites of mdg4, but it always hybridizes to the chromocenter. The location of mdg4 varies among D. melanoster strains. Blot hybridization shows that, in contrast to other mdg elements, mdg4 sequences are rather heterogeneous. Only few copies are full-length. A strong amplification of mdg4 has occurred during the in vitro cultivation of cells involving only one mdg4 variant.

Long terminal repeats (LTRs) and flanking sequences have been sequenced in two cloned copies of transposable element mdg4. In both cloned copies of mdg4 LTRs have an identical nucleotide sequence 479 bp long. The mdg4 is flanked by fourbase-pair direct repeats, short mismatched palindromes being present at the ends of each LTR. The termini of the mdg4 body contain an oligopurine stretch and a region partially complementary to D. melanogaster Formula Thus, structural organization of mdg4 LTRs is similar to that of several other mdg elements and retroviral proviruses.


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