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Nucleic Acids Research, 1984, Vol. 12, No. 9 3895-3907
© 1984

MOLECULAR BIOLOGY

Nucteotide sequences of bovine {alpha}S1- and x-casein cDNAs

A.F. Stewart, I.M. Willis and A.F. Mackinlay

School of Biochemistry, University of New South Wales Kensington 2033, Australia

Received October 18, 1983. Revised April 5, 1984. Accepted April 5, 1984.

The nucleotide sequences corresponding to bovine {alpha}S1- and k-casein mRNAs are presented. An unusual {alpha}S1-casein cDNA has been characterised whose 5' end commences upstream from its putative TATA box. The {alpha}S1- casein mRNA is compared to rat {alpha}S1-casein mRNA and two components of divergence are identified. Firstly, the two sequences have diverged at a high point mutation rate and the rate of amino acid replacement by this mechanism is at least as great as the rate of divergence of any other part of the mRNAs. Secondly, the protein coding sequence has been subjected to several insertion/deletion events, one of which may be an example of exon shuffling. The x-casein mRNA sequence verifies the proposition that it has arisen from a different ancestral gene to the other caseins.


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