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Nucleic Acids Research, 1985, Vol. 13, No. 10 3461-3470
© 1985

Articles

Structure and genomic organization of a new family of murine retrovirus-related DNA sequences (MuRRS)

Martin Schmidt, Thomas Wirth, Burkhard Kröger and Ivan Horak*

Institut für Virologie und Immunbiologie der Universität Würzburg Versbacher Strasse 7, D-8700 Würzburg, FRG

*To whom correspondaence should be addressed

Received March 11, 1985. Revised April 24, 1985. Accepted April 24, 1985.

A new class of murine retrovirus-related sequences (MuRRS) is described. These 5.7 kb long transposon-like DNA-elements start and end with ~ 600 bp long repeats identical to previously identified solitary LTR-like elements (LTR-IS). There are about 50 – 100 5.7 kb elements and about 500 – 1000 solo LTR-IS elements per mouse haploid genome. Sequence analysis of one cloned MuRRS element revealed several possible open reading frames with partial sequence homologies to retroviral gag, pol and env genes.


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