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Nucleic Acids Research, 1985, Vol. 13, No. 10 3581-3597
© 1985

Articles

rRNA proceesing: removal of only nineteen bas at the gap between 28S{alpha} and 28Sß rRNAs in Sciara coprophila

Vassie C. Ware, Rainer Renkawitz* and Susan A. Gerbi

Division of Biology and Medicine, Brown University Providence, RI 02912, USA

Received November 21, 1984. Revised April 18, 1985. Accepted April 18, 1985.

We have determined the sequence of the rDNA region between the 28S{alpha} and 28Sß rRRA coding segments (termed a "gap") in the insect Sciara corprophila and have used S1 nuclease mapping and cDNA primer extension to define the 5' and 3' boundaries of the gap. Only 19 bases found in rDNA at the gap region are absent from mature 28S rRNA. Eukaryotic rRNAs contain stretches of nucleotides ("expansion segments") which are absent in E. coli rRNA. The gap region in Sciara is located within expansion segment V. Therefore, the excision of 19 bases in the Sciara gap suggests that a large portion of expansion segment V plays no function in mature ribosomes. Specific sequences conserved in Sciara and Drosophila are considered as candidates for recognition signals for the excision of the gap transcript.

*Present Address: Gene Technology Groups, Max-Planck-Institut, D-8033 Martinsried, West Germany


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