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Nucleic Acids Research, 1985, Vol. 13, No. 10 3635-3649
© 1985

Articles

Synthesis of riboguanosine pentaphosphate ppprGpp (Magic Spot II) via a phosphotriester approach

Cecil Schattenkerk, Carel T. J. Wreesmann, Gijss A. van der Marel and Jacques H. van Boom*

Gorlaeus Laboratories, Department of Organic Chemistry P.O. Box 9502, 2300 RA Leiden, The Netherlands

*To whom corrospondence should be addxress

Received March 28, 1985. Accepted April 29, 1985.

The bifunctional phosphorylating reagent 0, 0-bis[1-benzotriazolyl]phospho-romorpholidate was used to introduce a 5'-0-triphosphate and a 3'-0-diphosphate function in a partially protected riboguanosine. Pilot studies indicated that protection of the 2'-OH of ribonucleosides with the acid-labile tetrahydropyranyl group, instead of the more labile 4-methoxytetrahydropyran-4-yl group, was most satisfactory for the preparation of the Magic Spot II.


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