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Nucleic Acids Research, 1985, Vol. 13, No. 13 4613-4622
© 1985

Articles

A highly polymorphic region 3' to the human Type II collagen gene

Neil G. Stoker, Kathryn S.E. Cheah*, Jane R. Griffin, F.M. Pope+ and Ellen Solomon

Somatic Cell Genetics Laboratory, Imperial Cancer Research Fund Laboratories P.O. Box 123, Lincoln's Inn Fields, London WC2A 3PX +MRC Clinical Research Centre, Northwick Park Hospital Harrow, Middlesex, UK

Received May 21, 1985. Revised June 14, 1985. Accepted June 14, 1985.

We have characterised a highly po1ymorphic region 1.3kb downstream of the human Type II collagen gene. It consists of a highly AT-rich tandem repetitive region (minisatellite) approximately 650bp long. Two alleles had been observed previously, differing in size by approximately 300bp. When this region was cloned from four four unrelated individuals carrying the larger allele, DNA sequence data identified three alleles, suggesting far higher polymorphism than was originally supposed. This minisatellite was shown to be present in a single copy in the human genome, and to have arisen after the divergence of Old and New World monkeys.

*Present address: Department of Biochemistry, Hong Kong University, Hong Kong


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