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Nucleic Acids Research, 1985, Vol. 13, No. 13 4739-4749
© 1985

Articles

A novel class of human type I interferons

Rudolf Hauptmann and Peter Swetly

Ernst-Boehringer-Institut für Arzneimittelforschung Dr. Boehringer-Gasse 5-11, A-1121 Vienna, Austria

Received April 12, 1985. Revised June 11, 1985. Accepted June 11, 1985.

The screening of a cDNA library prepared from mRNA of Senda1 virus induced Namalwa (human Burkitt's lymphoma) cells, using a human IFN-{alpha}2 DNA probe under conditions of low stringency, identified two weakly hybridizing clones containing sequences related to, but discernably different from those of the IFN-{alpha} class. Sequence and hybridization analysis of these cDNAs as well as expression in E.coli provided evidence that they encode proteins which have the characteristics of IFN type I but which are sufficiently diverged in sequence from both IEN-{alpha}s and IFN-ß to suggest that they are representatives of a new and distinct class of interferons named interferonomega. Hybridization of these sequences to genomic DNA reveals that this class contains at least four members.


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