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Nucleic Acids Research, 1985, Vol. 13, No. 13 4837-4851
© 1985

Articles

Human DNA sequene exhibiting gamete-speeille hypomethylatlon

Xian-Yang Zhang, Richard Y.-H. Wang and Melanie Ehrlich*

Department of Biochemistry, Tulane Medical School New Orleans, LA 70112, USA

*To whom correspondence should be addressed

Received March 7, 1985. Revised June 4, 1985. Accepted June 4, 1985.

Three human DNA sequences have been cloned from DNA regions which are strikingly undermethylated in sperm, highly methylated in adult somatic tissues, and methylated to an intermediate extent in tissues of extraembryonic origin. It is proposed that some such DNA sequences may function specifically early in embryogeneis or during gametogenesis. They may be subsequently extensively methylated in the embryonic cell lineage and methylated to a lesser extent in extraembryonic tissues in order to allow embryogenesis to proceed.


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