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Nucleic Acids Research, 1985, Vol. 13, No. 14 5085-5093
© 1985

Articles

Chromosomal rearrangements associated with LINE elements in the mouse genome

Susan Shyman and Steven Weaver

Laboratory of Cell, Molecular and Developmental Biology, Department of Biologicai Sciences, University of Illinois Box 4348, Chicago, IL 60680, USA

Received May 6, 1985. Revised June 10, 1985. Accepted June 19, 1985.

Two aegments of DNA that have apparently inserted in the interval between the two adult ß-globin genes in BALB/c (Hbbd haplotype) but not in C57B1/10 (Hbbs haplotype) mouse strains have been described (1). Theae putative insertions, each about 1000 bp in length, mapped near a repetitive element. To determine the precise position of these alleged insertions, their target sites, and the nature of their boundaries, we cloned and sequenced the appropriate regions of both chromosomes. One of the two segments is not an insertion but rather a region between two independently integrated Li repetitive elements (LINEs)(2), one in Hbbd and the other in the Hbbs chromosome. The other segment is an insertion of 940 bp which is located within the Li element in the Hbbd chromosome. This insert is unusual in that it exists in only one copy in the BALB/c genome.


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