Skip Navigation

This Article
Right arrow Print PDF (3696K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (11)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Higashi, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Higashi, Y.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1985, Vol. 13, No. 14 5157-5172
© 1985

Articles

Changes of Chromatin conformation around mouse interferon-ß gene associated with induction of interferon synthesis

Yujiro Higashi*

Department of Cellular and Molecular Virology, Institute for Virus Research, Kyoto University Sakyo-ku, Kyoto 606, Japan

Received March 21, 1985. Revised June 25, 1985. Accepted June 25, 1985.

Changes of chromatin structure around the mouse interferon-ß gene associated with induction were examined by the use of sensitivity to digestion with DNaseI. Upon induction, the DNaseI-sensitivity of mouse interferon-ß gene was increased and seven DNaseI-hypersensitive sites were mapped. One of them, which was located at approximately 100bp upstream and was insensitive in the uninduced state, showed a marked sensitivity upon induction. Four others, located at 580bp and 430bp upstream, and 1.9kb and 2.2kb downstream, whose levels of DNaseI-sensitivity were very low in the uninduced state, showed significant sensitivity in the induced state. Two remaining sites, located at 7.5kb upstream and 7.6kb downstream, had relatively high DNaseI-sensitivities even in the uninduced state and slightly increased their sensitivities upon induction.

*Present address: Department of Biochemistry, Cancer Institute, Japanese Foundation for Cancer Research, Kami-Ikebukuro, Toshima-ku, Tokyo 170, Japan


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Mol. Cell. Biol.Home page
H. Mokrani, O. Sharaf el dein, Z. Mansuroglu, and E. Bonnefoy
Binding of YY1 to the Proximal Region of the Murine Beta Interferon Promoter Is Essential To Allow CBP Recruitment and K8H4/K14H3 Acetylation on the Promoter Region after Virus Infection
Mol. Cell. Biol., November 15, 2006; 26(22): 8551 - 8561.
[Abstract] [Full Text] [PDF]

Home page
 J. Virol.Home page
L. Weill, E. Shestakova, and E. Bonnefoy
Transcription Factor YY1 Binds to the Murine Beta Interferon Promoter and Regulates Its Transcriptional Capacity with a Dual Activator/Repressor Role
J. Virol., March 1, 2003; 77(5): 2903 - 2914.
[Abstract] [Full Text] [PDF]

Home page
 J. Exp. Med.Home page
Y. Higashi, H. Moribe, T. Takagi, R. Sekido, K. Kawakami, H. Kikutani, and H. Kondoh
Impairment of  T Cell Development in delta EF1 Mutant Mice
J. Exp. Med., April 21, 1997; 185(8): 1467 - 1480.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.