Skip Navigation

This Article
Right arrow Print PDF (2424K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (37)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Wang, K.
Right arrow Articles by Pearson, G. D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wang, K.
Right arrow Articles by Pearson, G. D.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1985, Vol. 13, No. 14 5173-5187
© 1985

Articles

Adenovirus sequence required for replication in vivo

Kai Wang and George D. Pearson

Department of Biochemistry and Biophysics, Oregon State University Corvallis, OR 97331, USA

Received February 21, 1985. Revised June 3, 1985. Accepted June 17, 1985.

We have studied the in vivo replication properties of plasmids carrying deletion mutations within cloned adenovirus terminal sequences. Deletion mapping located the adenovirus DNA replication origin entirely within the first 67 bp of the adenovirus inverted terminal repeat. This region could be further subdivided into two functional domains: a minimal replication origin and an adjacent auxiliary region which boosted the efficiency of replication by more than 100-fold. The minimal origin occupies the first 18 to 21 bp and includes sequences conserved between all adenovirus serotypes. The adjacent auxiliary region extends past nucleotide 36 but not past nucleotide 67 and contains the binding site for nuclear factor I.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J. Gen. Virol.Home page
H. J. Rademaker, F. J. Fallaux, D. J. M. Van den Wollenberg, R. N. De Jong, P. C. Van der Vliet, and R. C. Hoeben
Relaxed template specificity in fowl adenovirus 1 DNA replication initiation.
J. Gen. Virol., March 1, 2006; 87(Pt 3): 553 - 562.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
L. das Neves, C. S. Duchala, F. Godinho, M. A. Haxhiu, C. Colmenares, W. B. Macklin, C. E. Campbell, K. G. Butz, and R. M. Gronostajski
Disruption of the murine nuclear factor I-A gene (Nfia) results in perinatal lethality, hydrocephalus, and agenesis of the corpus callosum
PNAS, October 12, 1999; 96(21): 11946 - 11951.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.