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Nucleic Acids Research, 1985, Vol. 13, No. 14 5283-5295
© 1985

Articles

The C. elegans vitellogenin genes: short sequence repeats in the promoter regions and homology to the vertebrate genes

John Spieth, Karen Denison, Sarah Kirtland, Jerome Cane and Thomas Blumenthal

Program in Molecular, Cellular and Developmental Biology, and Department of Biology, Indiana University Bloomington, IN 47405, USA

Received May 7, 1985. Accepted June 24, 1985.

The nematode Caenorhabditis elegans contains a small family of vitellogenin genes which is expressed abundantly, but only in the intestine of the adult hermaphrodite worm. In order to identify possible regulatory elements, we have sequenced the DNA surrounding the 5' ends of five of the six genes. Contained within regions which have largely diverged from one another, two different heptameric sequences are found repeated within the first 200 bp upstream of each of the genes. The first sequence, TGTCAAT, is present as a perfect heptamer at least once upstream of each gene. It is repeated in both orientations four to six times in each 5' flanking region, allowing a one-base mismatch. The second sequence, CTGATAA, is also present as a perfect heptsmer in a restricted region upstream of each gene. These two sequence elements may be involved in regulation of the vitellogenin genes. Remarkably, the CTGATAA sequence is present in a similar location in the promoter regions of vertebrate vitellogenin genes. In fact, our data reveal a surprising degree of similarity between the nematode and vertebrate vitellogenins.


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