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Nucleic Acids Research, 1985, Vol. 13, No. 15 5671-5684
© 1985

Articles

Nucleic acid binding drugs. Part XIII. Molecular motion in a drug-nucleic acid model system: thermal motion analysis of a proflavine-dinucleoside crystal structure

A.K. Aggarwal* and S. Neidle+

CRC Biomolecular Structure Unit, Institute of Cancer Research Sutton, Surrey SM2 5PX, UK

+To Whom Correspondence should be addressed

Received June 14, 1985. Accepted July 22, 1985.

The high-resolution crystal structure of the intercalation complex between proflavine and cytidylyl-3',5'-guanosine (CpG) has been studied by thermal-motion analysis. This has provided information on the translational and librational motions of individual groups in the complex. Many of these motions are similar to, though of larger magnitude than in uncomplexed dinucleosides. Pronounced librational effects were observed along the base pairs and in the plane of the drug chromophore.

1Present address: Department of Biochemistry and Molecular Biology, Hardward University, Cambridge, MA 021138, USA


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P Tang, C. Juang, and G. Harbison
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Science, July 6, 1990; 249(4964): 70 - 72.
[Abstract] [PDF]


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