Nucleic Acids Research, 1985, Vol. 13, No. 17 6361-6373
© 1985
Articles |
Human Lymphotoxin and tumor necrosis factor genes: structure, homology and chromosomal localization
Department of Molecular Biology, Genentech, Inc. 460 Point San Bruno Boulevard, South San Francisco, CA 94080 +Department of Cellular and Structural Biology, The University of Texas Health Science Center at San Antonio 7703 Floyd Curl Drive, San Antonio, TX 78284, USA
Received May 13, 1985. Revised August 10, 1985. Accepted August 10, 1985.
Human Tumor Necrosis Factor and Lymphotoxin are cytotoxic proteins which have similar biological activities and share 30 percent amino acid homology. The single copy genes which encode these proteins share several structural features: each gene is approximately three kilobase pairs in length and is interrupted by three introns. In addition, these genes are closely linked and have been mapped to human chromosome 6. However, only the last exons of both genes, which code for more than 80 percent of each secreted protein, are significantly homologous (56 percent).
*Molecular Therapeutics, Inc., 400 Morgan Lane, West Haven, Connecticut 06516.
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