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Nucleic Acids Research, 1985, Vol. 13, No. 18 6515-6529
© 1985

Articles

Subgroup IV of human immunoglobulin K light chains is encoded by a single germline gene

H.-Gustav Klobeck, Georg W. Bornkamm+, Gabriele Combriato, Ralph Mocikat, Hans-Dieter Pohlenz and Hans G. Zachau

Institut für Physiologische Chemie, Physikalische Biochemie und Zellbiologie der Universität München +Institut für Virologie, Zentrum für Hygiene, Universität Freiburg, FRG

Received July 5, 1985. Accepted September 6, 1985.

The series of studies on the human K light chain genes of the various subgroups is concluded by this report on the isolation and nucleotide sequence determination of a functional VKIV gene (abbreviations ref. 1) and its germline counterpart. The rearranged gene which stems from a lymphoid cell line and the germline gene differ in four nucleotides which can be attributed to somatic mutations; three of the mutations are clustered in CDR3. The germline gene regions of two unrelated individuals were identical over a stretch of 1267 bp. By hybridization experiments it is shown that the human K locus contains only one VKIV gene. In 16 lymphoid cell lines studied here, the VKIV gene is frequently deleted or aberrantly rearranged which may be a consequence of peculiarities of its function and/or Its structural organization.


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