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Nucleic Acids Research, 1985, Vol. 13, No. 18 6651-6661
© 1985

Articles

Sequence of the Dß2-Jß2 region of the human T-cell receptor ß-chain locus

A. Tunnacliffe and T.H. Rabbitts

Medical Research Council, Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH, UK

Received August 8, 1985. Accepted August 27, 1985.

We have sequenced the region encompassing a Dß2 segment and the Jß2 segments of the human T-cell antigen receptor ß-chain genes. The Dß2 element lies about 650 base pairs upstream of a cluster of seven potentially functional Jß2 sequences and one Jß2 pseudogene. Examination of human ß-chain cDNA sequences which involve rearranged Dß2 and Jß2 elements demonstrates that N-region, as well as junctional, diversity can occur during D-J Joining. Further, we present evidence for possible somatic mutation in active Jß2 segments.


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