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Nucleic Acids Research, 1985, Vol. 13, No. 19 7095-7106
© 1985

Articles

Nucleotide sequence of the transposon Tn7 gene encoding an aminoglycoside-modifying enzyme, 3''(9)-O-nucleotidyltransferase

Mary E. Flung, Jan Kopf and Cindy Richards

Wellcome Research Laboratories, Research Triangle Park NC 27709, USA

Received May 6, 1985. Revised September 5, 1985. Accepted September 5, 1985.

The nucleotide sequence of a transposon Tn7 DNA fragment encoding a 3''(9)-O-nucleotidyltransferase, an aminoglycoside-modifying enzyme, which mediates bacterial resistance to spectinomycin and Streptomycin, was determined. The aadA structural gene was 786 bases long and predicted a polypeptide of 262 amino acids with a calculated molecular weight of 29,207. Comparison of the DNA sequences of Tn7 and plasmid R538-1 indicated that their aadA genes were nearly identical. Comparison of the polypeptides predicted by the aadA genes of Tn7 and Tn554 Indicated that the genes were related.


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