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Nucleic Acids Research, 1985, Vol. 13, No. 19 7153-7166
© 1985

Articles

Chemical adaptation of M. luteus induces repair functions for O-alkylated DNA pyrimidines+

S. Riazuddin, A. Athar and R. Saffhill*

Centre for Advanced Molecular Biology, University of the Punjab Lahore, Pakistan

Received July 23, 1985. Revised September 10, 1985. Accepted September 10, 1985.

A partially purified extract prepared from adapted M. luteus cells contains repair functions for oxygen methylated pyrimidine residues present in alkylated DNA. The removal of O2-MeT is mediated by a DNA glycosylase enzyme whereas disappearance of O4-MeT is effected by a methyltransferase in a manner similar to the in situ repair of O6-MeG. O4-MeT methyltransferase enzyme is unusually heat resistant. Synthesis of these repair proteins, which are distinctly different from the previously known inducible 3-MeA DNA glycosylase and O6-MeG methyltransferase activities, forms a part of the adaptive response.

+ This investigation, supported by the United States National Science Foundation, was initiated at the Nuclear Institute for Agriculture and Biology, Faisalabad, Pakistan.

* Permanent address: Paterson Laboratories, Christie Hospital and Holt Radium Institute, Manchester M20 9BX


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