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Nucleic Acids Research, 1985, Vol. 13, No. 2 449-458
© 1985

Articles

Sequence specific damage of DNA induced by reducing sugars

Junji Morita, Kazumitsu Ueda1, Satoshi Nanjo2 and Tohru Komanol1,*

Department of Food Science, Doshisha Women's College of Liberal Arts Kyoto 602 1Department of Agricultural Chemistry, Kyoto University Kyoto 606 2Department of Agricultural Chemistry, Kyoto Prefectural University Kyoto 606, Japan

*To whom correspondance should be addressed

Received September 26, 1984. Revised January 3, 1985. Accepted January 3, 1985.

Reducing sugars induced alkali-labile sites in DNA. The D reacted with D-fructose 6-phosphate or D-fructose in the presence of Cu2+ was cleaved by the treatment with aqueous piperidine at 90°C for 30 min. Alkali-labile sites were induced frequently at the pyrimidine residues, especially at the pyrimidine residues pyrimidine-purmne (5'<-3') sequences. Transition metal ions such as Cu2+ and oxygen radicals such as hydrogen peroxide were possibly involved in the induction of alkali-labile sites.


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