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Nucleic Acids Research, 1985, Vol. 13, No. 20 7257-7268
© 1985

Articles

The nucleotide sequence of the yeast MEL1 gene

Pirkko L. Liljeström

Research Laboratories of the Finnish State Alcohol Company (Alko Ltd) PO Box 350, SF-00101 Helsinki, Finland

Received August 13, 1985. Revised September 26, 1985. Accepted September 26, 1985.

The complete nucleotide sequence of the MEL1 gene of the yeast, Saccharomyces cerevisiae, encoding {alpha}-galactosidase was determined. The nucleotide sequence contains an open reading frame of 1413 bp encoding a protein of 471 amino acids. Comparison with the known N-terminal amino acid sequence of the mature secreted protein indicated that {alpha}-galactosidase is synthesized as a precursor with an N-terminal signal sequence of 18 amino acids. The general features of this signal peptide resemble those of other yeast signal peptides. Molecular weight of the mature {alpha}-galactosidase polypeptide deduced from the nucleotide sequence is 50.049 kd. The 5' regulatory region has sequences in common with other yeast genes regulated by the GAL4-protein.


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