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Nucleic Acids Research, 1985, Vol. 13, No. 20 7515-7528
© 1985

Articles

The genomic organisation and nucleotide sequence of the HLA-SB(DP) alpha gene

Simon K. Lawrance1, Hriday K. Das2,*, Julian Pan2 and Sherman M. Weissman2

1Department of Biology, Yale University New Haven, CT 06520, USA 2Department of Human Genetics, Yale University New Haven, CT 06520, USA

Received July 9, 1985. Revised September 9, 1985. Accepted September 11, 1985.

We have isolated a unique fragment of the HLA-DR alpha gene and probed human genomic DNA at low stringency to search for homologous sequences. A minimum of six non-polymorphic cross-hybridizing high molecular weight fragments were found in all DNAs examined. In order to obtain molecular clones of these cross-hybridizing fragments, we constructed lambda and cosmid libraries of human DNA and screened them at low stringency with the HLA-DR alpha gene specific subclone. We have isolated clones corresponding to each of the six fragments and, in this paper, describe those which contain the gene encoding HLA-SB(DP) alpha.

*Present address: Rockefeller University, New York, NY 10021, USA


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