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Nucleic Acids Research, 1985, Vol. 13, No. 22 8119-8128
© 1985

Articles

Nucleotide sequence encoding the biosynthetic dehydroquinase function of the penta-functional AROM locus of Aspergillus nidulans

Ian G. Charles, John W. Keyte, William J. Brammar and Alastair R. Hawkins*,

Department of Biochemistry, School of Biological Sciences, University of Leicester Leicester LEI 7RH, UK Department of Genetics, Ridley Building, University of Newcastle upon Tyne Newcastle upon Tyne NE1 7RU, UK

*To whom correspondence should be addressed

Received October 8, 1985. Accepted October 22, 1985.

The nucleotide sequence of a 1.9 Kb HindIII fragment of DNA derived from the AROM locus of A.nidulans and encoding the biosynthetic dehydroquinase activity has been determined. The sequences encoding the biosynthetic and catabolic dehydroquinase enzymes of A.nidulans show no detectable homology, strongly suggesting convergent evolutionary pathways. The messenger RNA specified by the AROM locus was detected a3 a 5.3 Kb RNA species.


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