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Nucleic Acids Research, 1985, Vol. 13, No. 22 8231-8246
© 1985

Articles

Sequence of the Saccharomyces cerevisiae PHRI gene and homology of the PHRI photolyase to E. coli photolyase

Gwendolyn B. Sancar

Department of Biochemistry 231H, University of North Carolina, Chapel Hill, NC 27514, USA

Received August 12, 1985. Revised October 24, 1985. Accepted October 24, 1985.

The nucleotide sequence of a 2301 base pair region of Saccharomyces carevisiae DNA containing the PHRI gene is reported. Within this region a single open reading frame of 1695 base pairs was found; using the insertional inactivation technique it was shown that part or all of this open reading frame specifies the PHRI-encoded photolyase. The amino acid sequence of the 565 amino acid long polypeptide predicted from the PHRI nucleotide sequence was compared to the amino acid sequence of E. coli photolyase. Overall the sequence homology was 36.5%; however, two short regions near the amino terminus as well as the carboxy-terminal 150 amino acids display significantly greater sequence homology. The presence of these strongly conserved regions suggests that the yeast and E. coli photolyase possess common structural and functional domains involved in substrate and/or chromophore binding.


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