Nucleic Acids Research, 1985, Vol. 13, No. 23 8463-8475
© 1985
Articles |
The yeast 
-factor receptor: structural properties deduced from the sequence of the STE2 gene
Department of Genetics, SK-50, University of Washington Seattle, WA 98195, USA
*To whom correspondence should be addressed
Received July 29, 1985. Revised October 23, 1985. Accepted October 29, 1985.
The STE2 gene of the yeast Saccharomyces cerevisiae encodes a component of the receptor for the oligopeptide pheromone 
-factor (1). We have cloned and determined the nucleotide sequence of the STE2 gene. A sequence involved in the control of cell-type expression of the STE2 gene (2,3) was found 5' of an open reading frame that could encode a protein of 431 amino acids. The predicted STE2 protein contains seven hydrophobic segments, suggesting that the -factor receptor is an integral membrane protein. No extensive homology at the primary sequence level was detected between the predicted STE2 protein and other available protein sequences.
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