Nucleic Acids Research, 1985, Vol. 13, No. 3 825-839
© 1985
Articles |
Characterization of a mouse interferon gene locus II. Differential expression of 
-interferon genes
Oncology Center 1-109. Johns Hopkins University School of Medicine 600 North Wolfe St., Baltimore, MD 21205, USA
*To whom correspondence should be addressed
Received November 20, 1984. Revised January 9, 1985. Accepted January 9, 1985.
A cluster of four MuIFN-
genes was recently isolated and characterized (1); one of the genes in this cluster had, in the coding region, an internal deletion of 5 amino acids. Bacterial expression plasmids were constructed to examine the effect of this deletion on the antiviral activity of the MuIFN-4 peptide and it was found that 4 interferon peptide had a 100-fold lower antiviral activity than full length -interferon proteins when expressed in E.coli.
Three of the four MuIFN- genes identified were expressed coordinately in L-cells infected with NDV. The relative levels of 4 mRNA were substantially higher than the levels of the other mRNAs. Comparison of the 5' end flanking sequences of these four a interferon genes revealed that the promoter sequences of 1, 5 and 6 are more homologous to each other than to the 4 promoter which also contains a G rich cluster not seen in the other three promoters.
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