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Nucleic Acids Research, 1985, Vol. 13, No. 5 1505-1516
© 1985

Articles

Nucleotide sequence of mouse IL-2 receptor cDNA and its comparison with the human IL-2 receptor sequence

Akira Shimuzu1, Shigeru Kondo3, Shun-ichi Takeda3, Junji Yodoi2, Norio Ishida1, Hisataka Sabe1, Hisao Osawa4, Tibor Diamantstein4, Toshio Nikaido1 and Tasuku Honjo1,3

1Department of Medical Chemistry Kyoto 606 2Institute for Immnunology, Kyoto University Faculty of Medicine Kyoto 606 3Department of Genetics, Osaka University Medical School Osaka 530, Japan 4The Immunology Research Unit Klinikum, Steglitz, Freie Universität Berlin, FRG

Received December 31, 1984. Revised February 14, 1985. Accepted February 14, 1985.

We have cloned cDNA encoding the mouse interleukin-2(IL-2) receptor from a murine T cell line, CTLL using human IL-2 receptor cDNA as probe. COS 7 cells transfected with the cDNA expressed the antigen recognized by the monoclonal antibody against the murine IL-2 receptor. The cDNA identified 4 species of mRNA (4.5, 3.5, 2.2 and 1.5 kb) of the mouse IL-2 receptor in CTLL cells. Difference in the length of mRNA seems to be ascribed to the variable length of the 3' untranslated sequence. Total nucleotide sequence ({small tilde}1400 bp) of this cDNA was determined and compared with the human receptor. The nucleotide and amino acid sequences of the IL-2 receptor are 70% and 60%, respectively, homologous in average between the two species. The comparison has revealed several conserved regions localized to particular exons such as transmembrane and cytoplasmic portions, suggesting that these regions are important for receptor function and its regulation.


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