Nucleic Acids Research, 1985, Vol. 13, No. 5 1607-1621
© 1985
Articles |
Complete nucleotide sequence of a functional HLA-DPß gene and the region between the DPß1 and DP
1 genes: comparison of the 5' ends of HLA class II genes
Imperial Cancer Research Fund, 44 Lincoln's Inn Fields London, WC2A 3PX, UK
Received January 4, 1985. Accepted January 29, 1985.
The complete nucleotide sequence of an HLA-DPß1 gene and part of the adjacent DP
1 gene, up to and including the signal sequence exon, were determined. The sequence of the DPß1 gene identified it as the DPw4 allele. The six exons of the DPß1 gene spanned over 11,000 bp of sequence. The arrangement of the gene was broadly analogous to genes of other class II ß chains. The ß1 exon was flanked by introns of over 4 kb. Comparisons with published sequences of cDNA clones indicated that an alternative splice junction, at the 3' end of the gene, is used in at least one allele. Variation in choice of splice junction indicates an additional mechanism for allelic variation in class II genes. The sequence also indicated that the DPß1 and DP1 genes are separated by only 2 kb at their 5' ends. Comparison of the 5' ends of the DP1 and ß1 genes with other class II sequences, including the DZ gene, showed conservation of several blocks of sequences thought to be involved in control of expression. Some areas of the introns were partially conserved in the DQß gene, and several other intron sequences were homologous to sequences found in other unrelated genes.
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