Nucleic Acids Research, 1985, Vol. 13, No. 5 1717-1731
© 1985
Articles |
A new principle of RNA folding based on pseudoknotting
Department of Biochemistry, State University of Leiden Wassenaarseweg 64, 2333 AL Leiden, The Netherlands
Received December 3, 1984. Revised February 5, 1985. Accepted February 5, 1985.
Tertiary interactions involving hairpin or interior loops of RNA can lead to extended quasi-continuous double helical stem regions, consisting of coaxially stacked segments of duplex RNA, bridged by single-stranded connections. This type of compact folding plays a role in various strategic regions of RNA molecules. Their role in ribosome functioning, RNA splicing and recognition of tRNA-like structures is discussed.
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