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Nucleic Acids Research, 1985, Vol. 13, No. 6 2171-2186
© 1985

Articles

Localization and characterization of members of a family of repetitive sequences in the goat ßglobin locus

Sally E. Spence, Regina M. Young, Karen J. Garner and Jerry B. Lingrel*

University of Cincinnati College of Medicine, Department of Microbiology and Molecular Genetics 231 Bethesda Avenue, Cincinnati, OH 45267-0524, USA

*To whom correspondence and reprint requests should be addressed

Received November 9, 1984. Revised February 4, 1985. Accepted February 4, 1985.

We have characterized a family of repetitive DNA elements in the ß-globin locus of the goat. These sequences are structurally analogous to the Alu families of repeats of other mammals. Repetitive elements are located both in the intervening sequences and in the intergenic regions of the goat ß-globin locus. Nucleotide sequence analysis of five repetitive elements located within the large intervening sequence of the ß-like globin genes, and four repeats located 5' to the major developmentally regulated ß-globin genes has resulted in the definition of a consensus sequence for this family of repeats.


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