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Nucleic Acids Research, 1985, Vol. 13, No. 8 2843-2853
© 1985

Articles

The involvement of histone H1° in chromatin structure

Joëlle Roche*, Jean-Luc Girardet, Claude Gorka and Jean-Jacques Lawrence+

Laboratoire de Biologie Moléculaire du Cycle Cellulaire, Département de Recherche Fondamentale, Centre d'Etudes Nucléaires de Grenoble 85 X, 38041 Grenoble Cedex, France

+To whom correspondence should be addressed

Received November 30, 1984. Accepted March 18, 1985.

Micrococcal nuclease digestion and light scattering are used to compare native chromatins with various histone H1° contents. The experimental data show that the higher the H1° content, the greater the ability to form compact structures with increasing ionic strength, and the lower the DNA accessibility to micrococcal nuclease. On the contrary, reconstituted samples from H1-depleted chromatin and pure individual H1 fractions behave in such a way that samples reconstituted with pure H1° give rise to a looser structure, more accessible to nuclease than samples reconstituted with H1-1.

This contradiction suggests that the effect of H1° on chromatin structure must originate from the interaction of this histone with other components in native chromatin among which other histone H1 subfractions are good candidates.

*Present address: Laboratoire de Biologie Moléculaire, Université de Lyon I, 69622 Villeurbanne Cedex, France


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