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Nucleic Acids Research, 1985, Vol. 13, No. 8 2959-2977
© 1985

Articles

Chemical synthesis of a gene for somatomedin C

Brian S. Sproat* and Michael J. Gait

Laboratory of Molecular Biology, Medical Research Council Centre Hills Road, Cambridge CB2 2QH, UK

+To whom correspondence should be addressed. Present address: European Molecular Biology Laboratory, Meyerhofstrasse 1, D-6900 Heidelberg, FRG

Received January 30, 1985. Accepted February 25, 1985.

A synthetic gene for somatomedin C, a human growth factor, has been assembled by a single ligation of 23 oligodeoxy-ribonucleotides, which were chemically synthesized by an improved solid phase phosphotriester method.


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