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Nucleic Acids Research, 1985, Vol. 13, No. 9 3241-3260
© 1985

Articles

The divergent region of the Leishmania tarentolae kinetoplast maxicircle DNA contains a diverse set of repetitive sequences

Michael L. Muhich, Nicolas Neckelmann* and Larry Simpson+

Department of Biology and Molecular Biology Institute, University of California Los Angeles, CA, 90024, USA

Received February 4, 1985. Revised April 9, 1985. Accepted April 9, 1985.

A 2.76 kb segment of the 12 kb divergent region of the Leishmania tarentolae kinetoplast maxicircle DNA consists almost entirely of repeated sequences. The repeats can be grouped into six families, some of which are present throughout the remainder of the divergent region. The repeats are oriented in a head-to-tail fashion with the three simplest repeats clustered into large arrays. A 47 bp palindrome and two copies of a "supercluster" of three different types of repeats are also present in the sequenced region. A sequence change in the divergent region is described for a clonal strain of L. tarentolae which was passaged continuously for several years. The repetitive sequences found in the divergent region appear to be appropriate substrates for the presumed deletion/insertion/recombination events occuring in this rapidly evolving portion of the maxicircle.

*Current address; Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322

+To whom reprint requests should be addressed


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