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Nucleic Acids Research, 1986, Vol. 14, No. 1 327-334
© 1986

Articles

PEPPLOT, a protein secondary structure analysis program for the UWGCG sequence analysis software package*

Michael Gribskov1, Richard R. Burgess2 and John Devereux3

1Molecular Biology Institute, Department of Chemistry, University of California Los Angeles, CA 2McArdle Laboratory for Cancer Research, University of Wisconsin Madison, WI 53706, USA 3University of Wisconsin Genetics Computer Group, UW Biotechnology Center 1710 University Avenue, Madison, WI 53705, USA

Received July 17, 1985.

We describe a program for the analysis of protein secondary structure that operates with the Sequence Analysis Software Package of the University of Wisconsin Genetics Computer Group (UWGCG). The program produces both graphic and printed output. Structure prediction using the Chou and Fasman and Robson et al methods, and hydropathy analysis by the method of Kyte and Doolittle are included along with a simplified method of hydrophobic moment analysis. The power of the program is the coordinated presentation of nany different kinds of structural information on the same plot.

* PEPPLOT is distributed as a part of the UWGCG Sequence Analysis Software Package described in reference 6. The package is available for $2,400 (non-profit) or $4,800 (commercial) from John Devereux, UW Biotechnology Center, 1710 University Avenue, Hadison, Wisconsin 53705, USA, (608) 263–8970.


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