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Nucleic Acids Research, 1986, Vol. 14, No. 11 4683-4690
© 1986


Articles

A new method for predicting signal sequence cleavage sites

Gunnar von Heijne

Research Group for Theoretical Biophysics, Department of Theoretical Physics, Royal Institute of Technology S-100 44 Stockholm, Sweden

Received March 5, 1986. Revised May 5, 1986. Accepted May 5, 1986.

A new method for identifying secretory signal sequences and for predicting the site of cleavage between a signal sequence and the mature exported protein is described. The predictive accuracy is estimated to be around 75–80% for both prokaryotic and eukaryotic proteins.


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Biol. Reprod.Home page
T. Sasanami, M. Toriyama, and M. Mori
Carboxy-Terminal Proteolytic Processing at a Consensus Furin Cleavage Site Is a Prerequisite Event for Quail ZPC Secretion
Biol Reprod, May 1, 2003; 68(5): 1613 - 1619.
[Abstract] [Full Text] [PDF]


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MicrobiologyHome page
K.-P. Fuchs, V. V. Zverlov, G. A. Velikodvorskaya, F. Lottspeich, and W. H. Schwarz
Lic16A of Clostridium thermocellum, a non-cellulosomal, highly complex endo-{beta}-1,3-glucanase bound to the outer cell surface
Microbiology, April 1, 2003; 149(4): 1021 - 1031.
[Abstract] [Full Text] [PDF]


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Proc. Natl. Acad. Sci. USAHome page
J. B. Welsh, L. M. Sapinoso, S. G. Kern, D. A. Brown, T. Liu, A. R. Bauskin, R. L. Ward, N. J. Hawkins, D. I. Quinn, P. J. Russell, et al.
Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum
PNAS, March 18, 2003; 100(6): 3410 - 3415.
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J. Biol. Chem.Home page
A. Adisa, M. Rug, N. Klonis, M. Foley, A. F. Cowman, and L. Tilley
The Signal Sequence of Exported Protein-1 Directs the Green Fluorescent Protein to the Parasitophorous Vacuole of Transfected Malaria Parasites
J. Biol. Chem., February 14, 2003; 278(8): 6532 - 6542.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
R. C. Lee, M. Hrmova, R. A. Burton, J. Lahnstein, and G. B. Fincher
Bifunctional Family 3 Glycoside Hydrolases from Barley with alpha -L-Arabinofuranosidase and beta -D-Xylosidase Activity. CHARACTERIZATION, PRIMARY STRUCTURES, AND COOH-TERMINAL PROCESSING
J. Biol. Chem., February 7, 2003; 278(7): 5377 - 5387.
[Abstract] [Full Text] [PDF]


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Appl. Environ. Microbiol.Home page
A. M. Lopez-Contreras, A. A. Martens, N. Szijarto, H. Mooibroek, P. A. M. Claassen, J. van der Oost, and W. M. de Vos
Production by Clostridium acetobutylicum ATCC 824 of CelG, a Cellulosomal Glycoside Hydrolase Belonging to Family 9
Appl. Envir. Microbiol., February 1, 2003; 69(2): 869 - 877.
[Abstract] [Full Text] [PDF]


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J. Clin. Microbiol.Home page
P. C. Y. Woo, K. T. K. Chong, A. S. P. Leung, S. S. Y. Wong, S. K. P. Lau, and K.-Y. Yuen
AFLMP1 Encodes an Antigenic Cell Wall Protein in Aspergillus flavus
J. Clin. Microbiol., February 1, 2003; 41(2): 845 - 850.
[Abstract] [Full Text] [PDF]


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EndocrinologyHome page
Y. Wang and W. Ge
Involvement of Cyclic Adenosine 3',5'-Monophosphate in the Differential Regulation of Activin {beta}A and {beta}B Expression by Gonadotropin in the Zebrafish Ovarian Follicle Cells
Endocrinology, February 1, 2003; 144(2): 491 - 499.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
L. C. Gowen, D. N. Petersen, A. L. Mansolf, H. Qi, J. L. Stock, G. T. Tkalcevic, H. A. Simmons, D. T. Crawford, K. L. Chidsey-Frink, H. Z. Ke, et al.
Targeted Disruption of the Osteoblast/Osteocyte Factor 45 Gene (OF45) Results in Increased Bone Formation and Bone Mass
J. Biol. Chem., January 10, 2003; 278(3): 1998 - 2007.
[Abstract] [Full Text] [PDF]


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J. Bacteriol.Home page
N. Winterhoff, R. Goethe, P. Gruening, M. Rohde, H. Kalisz, H. E. Smith, and P. Valentin-Weigand
Identification and Characterization of Two Temperature-Induced Surface-Associated Proteins of Streptococcus suis with High Homologies to Members of the Arginine Deiminase System of Streptococcus pyogenes
J. Bacteriol., December 15, 2002; 184(24): 6768 - 6776.
[Abstract] [Full Text] [PDF]


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MicrobiologyHome page
D. M. Soden, J. O'Callaghan, and A. D. W. Dobson
Molecular cloning of a laccase isozyme gene from Pleurotus sajor-caju and expression in the heterologous Pichia pastoris host
Microbiology, December 1, 2002; 148(12): 4003 - 4014.
[Abstract] [Full Text] [PDF]


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Plant Physiol.Home page
M. Mizutani, H. Nakanishi, J.-i. Ema, S.-J. Ma, E. Noguchi, M. Inohara-Ochiai, M. Fukuchi-Mizutani, M. Nakao, and K. Sakata
Cloning of beta -Primeverosidase from Tea Leaves, a Key Enzyme in Tea Aroma Formation
Plant Physiology, December 1, 2002; 130(4): 2164 - 2176.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
Y. Terao, S. Kawabata, M. Nakata, I. Nakagawa, and S. Hamada
Molecular Characterization of a Novel Fibronectin-binding Protein of Streptococcus pyogenes Strains Isolated from Toxic Shock-like Syndrome Patients
J. Biol. Chem., November 27, 2002; 277(49): 47428 - 47435.
[Abstract] [Full Text] [PDF]


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MicrobiologyHome page
K. P. Mintz, J. Moskovitz, H. Wu, and P. M. Fives-Taylor
Peptide methionine sulfoxide reductase (MsrA) is not a major virulence determinant for the oral pathogen Actinobacillus actinomycetemcomitans
Microbiology, November 1, 2002; 148(11): 3695 - 3703.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
K. Peoc'h, C. Serres, Y. Frobert, C. Martin, S. Lehmann, S. Chasseigneaux, V. Sazdovitch, J. Grassi, P. Jouannet, J.-M. Launay, et al.
The Human "Prion-like" Protein Doppel Is Expressed in Both Sertoli Cells and Spermatozoa
J. Biol. Chem., November 1, 2002; 277(45): 43071 - 43078.
[Abstract] [Full Text] [PDF]


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J. Virol.Home page
R. Wieringa, A. A. F. de Vries, M. J. B. Raamsman, and P. J. M. Rottier
Characterization of Two New Structural Glycoproteins, GP3 and GP4, of Equine Arteritis Virus
J. Virol., October 2, 2002; 76(21): 10829 - 10840.
[Abstract] [Full Text] [PDF]


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J. Gen. Virol.Home page
R. S. Hilgarth and B. A. Webb
Characterization of Campoletis sonorensis ichnovirus segment I genes as members of the repeat element gene family
J. Gen. Virol., October 1, 2002; 83(10): 2393 - 2402.
[Abstract] [Full Text] [PDF]


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J. Gen. Virol.Home page
A. M.-J. Sasseville, M. Boutin, A.-M. Gelinas, and S. Dea
Sequence of the 3'-terminal end (8{middle dot}1 kb) of the genome of porcine haemagglutinating encephalomyelitis virus: comparison with other haemagglutinating coronaviruses
J. Gen. Virol., October 1, 2002; 83(10): 2411 - 2416.
[Abstract] [Full Text] [PDF]


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MicrobiologyHome page
J. Tolle, K.-P. Michel, J. Kruip, U. Kahmann, A. Preisfeld, and E. K. Pistorius
Localization and function of the IdiA homologue Slr1295 in the cyanobacterium Synechocystis sp. strain PCC 6803
Microbiology, October 1, 2002; 148(10): 3293 - 3305.
[Abstract] [Full Text] [PDF]


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J. Biol. Chem.Home page
Y. Shimomura, M. Harada, M. Goto, T. Sugo, Y. Matsumoto, M. Abe, T. Watanabe, T. Asami, C. Kitada, M. Mori, et al.
Identification of Neuropeptide W as the Endogenous Ligand for Orphan G-protein-coupled Receptors GPR7 and GPR8
J. Biol. Chem., September 20, 2002; 277(39): 35826 - 35832.
[Abstract] [Full Text] [PDF]


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J. Bacteriol.Home page
T. Li, X. Huang, R. Zhou, Y. Liu, B. Li, C. Nomura, and J. Zhao
Differential Expression and Localization of Mn and Fe Superoxide Dismutases in the Heterocystous Cyanobacterium Anabaena sp. Strain PCC 7120
J. Bacteriol., September 15, 2002; 184(18): 5096 - 5103.
[Abstract] [Full Text] [PDF]


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Appl. Environ. Microbiol.Home page
M. Saloheimo, J. Kuja-Panula, E. Ylosmaki, M. Ward, and M. Penttila
Enzymatic Properties and Intracellular Localization of the Novel Trichoderma reesei {beta}-Glucosidase BGLII (Cel1A)
Appl. Envir. Microbiol., September 1, 2002; 68(9): 4546 - 4553.
[Abstract] [Full Text] [PDF]


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Appl. Environ. Microbiol.Home page
N. Agrawal, P. Malhotra, and R. K. Bhatnagar
Interaction of Gene-Cloned and Insect Cell-Expressed Aminopeptidase N of Spodoptera litura with Insecticidal Crystal Protein Cry1C
Appl. Envir. Microbiol., September 1, 2002; 68(9): 4583 - 4592.
[Abstract] [Full Text] [PDF]


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MicrobiologyHome page
M. Bernard, I. Mouyna, G. Dubreucq, J.-P. Debeaupuis, T. Fontaine, C. Vorgias, C. Fuglsang, and J.-P. Latge
Characterization of a cell-wall acid phosphatase (PhoAp) in Aspergillus fumigatus
Microbiology, September 1, 2002; 148(9): 2819 - 2829.
[Abstract] [Full Text] [PDF]


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Genome ResHome page
D. S. Hekmat-Scafe, C. R. Scafe, A. J. McKinney, and M. A. Tanouye
Genome-Wide Analysis of the Odorant-Binding Protein Gene Family in Drosophila melanogaster
Genome Res., September 1, 2002; 12(9): 1357 - 1369.
[Abstract] [Full Text] [PDF]


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Infect. Immun.Home page
M. E. Sebert, L. M. Palmer, M. Rosenberg, and J. N. Weiser
Microarray-Based Identification of htrA, a Streptococcus pneumoniae Gene That Is Regulated by the CiaRH Two-Component System and Contributes to Nasopharyngeal Colonization
Infect. Immun., August 1, 2002; 70(8): 4059 - 4067.
[Abstract] [Full Text] [PDF]


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EndocrinologyHome page
D. Alexandre, H. Vaudry, L. Grumolato, V. Turquier, A. Fournier, S. Jegou, and Y. Anouar
Novel Splice Variants of Type I Pituitary Adenylate Cyclase-Activating Polypeptide Receptor in Frog Exhibit Altered Adenylate Cyclase Stimulation and Differential Relative Abundance
Endocrinology, July 1, 2002; 143(7): 2680 - 2692.
[Abstract] [Full Text] [PDF]


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Biol. Reprod.Home page
B. Nixon, C. M. Hardy, R. C. Jones, J. B. Andrews, and M. K. Holland
Rabbit Epididymal Secretory Proteins. III. Molecular Cloning and Characterization of the Complementary DNA for REP38
Biol Reprod, July 1, 2002; 67(1): 147 - 153.
[Abstract] [Full Text] [PDF]


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J. Cell Sci.Home page
X. Kang, A. Szallies, M. Rawer, H. Echner, and M. Duszenko
GPI anchor transamidase of Trypanosoma brucei: in vitro assay of the recombinant protein and VSG anchor exchange
J. Cell Sci., June 15, 2002; 115(12): 2529 - 2539.
[Abstract] [Full Text] [PDF]


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J. Bacteriol.Home page
F. Okazaki, Y. Tamaru, S. Hashikawa, Y.-T. Li, and T. Araki
Novel Carbohydrate-Binding Module of {beta}-1,3-Xylanase from a Marine Bacterium, Alcaligenes sp. Strain XY-234
J. Bacteriol., May 1, 2002; 184(9): 2399 - 2403.
[Abstract] [Full Text] [PDF]



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