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Nucleic Acids Research, 1986, Vol. 14, No. 12 4803-4821
© 1986

Articles

Cross-linking of initiation factor IF3 to Escherichia coli 30S ribosomal subunit by trans-dlamminedichloroplatinum(II): characterization of two cross-linking sites in 16S rRNA; a possible way of functioning for IF3

Chantal Ehresmann*, Hervè Moine, Marylène Mougel, Jacques Dondon+, Marianne Grunberg-Manago+, Jean-Pierre Ebel and Bernard Ehresmann

Institut de Biologic Molèculaire et Cellulaire du CNRS, Laboratoire de Biochimie 15, rue Renè Descartes, 67084 Strasbourg Cedex +Institut de Biologie Physico-Chimique 13, rue Pierre et Marie Curie, 75005 Paris, France

*To whom correspondence should be addressed

Received April 4, 1986. Revised May 16, 1986. Accepted May 16, 1986.

The Initiation factor IF3 is platinated with trans-d1anm1ne-d1chloroplat1num(II) and cross-linked to Escherichia coli 30S ribosomal subunit. Two cross-linking sites are unambiguously identified on the 16S rRNA : a major one, in the region 819–859 1n the central domain, and a minor one, 1n the region 1506–1529 1n the 3'-term1nal domain. Specific features of these sequences together with their particular location within the 30S subunit lead us to postulate a role for IF3, that conciliates topographical and functional observations made so far.


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