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Nucleic Acids Research, 1986, Vol. 14, No. 14 5629-5640
© 1986

Articles

Isolation of cDNA clones derived from a cellular gene transcriptionally induced by Herpes Simplex Virus

R. Patel, W.L. Chan*, L.M. Kemp, N.B.La Thangue* and D.S. Latchman

Department of Zoology, University College London WC1E 6BT, UK *ICRF Tumour Immunology Unit, University College London WC1E 6BT, UK

Received May 23, 1986. Revised June 24, 1986. Accepted July 1, 1986.

A small number of cellular proteins accumulate to high levels in cells infected with Herpes Simplex Virus (HSV) despite a generalised repression of most host cell bio-synthesis. An antibody to one such protein has been used to screen a lambda gtll library and far polysome immunoprecipitation in order to isolate cDNA clones derived from the corresponding gene. The cDNA clones have been used in dot blot and nuclear run-off assays to show that HSV, like other DNA tumour viruses can transcriptionally induce a cellular gene. The mechanism of this effect which is dependent on viral protein synthesis and its possible significance in transformation by HSV are discussed.


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